Trifluoroacetic acid → HCID 10158467, compound

Participants

Reaction Steps

tert-Butyl 6-benzyl-8-(2,4-dichlorophenyl)-3,4,4a,9b-tetrahydro[1]benzofuro[3,2-c]pyridine-2(1H)-carboxylate (0.137 g, 0.270 mmol) was dissolved in CH2Cl2 (5 mL). Trifluoracetic acid (0.44 mL, 5.670 mmol) was added and the reaction mixture was stirred at rt under N2 for 4 h. The reaction mixture was cooled to 0° C. and 25% aqueous NaOH (15 mL) was added. The reaction mixture was partitioned between CH2Cl2 and water. The water layer was extracted with CH2Cl2 (2×). The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure. The crude was purified by chromatography (1% NH4OH, 5.95% CH3OH, 93.05% CH2Cl2), and Example 250 was obtained in 86% yield. MS (ESI+) for C24H21Cl2NO m/z 410.0 (M+H)+.

Provenance & Evidence