HCID 12125209, compound → HCID 23508408, compound

Participants

Reaction Steps

262 mg of 2′-cyano-4′-nitrobiphenyl-4-yl sulfamate was dissolved in 2.5 ml of formic acid, and 445 mg of 10% palladium-carbon was added thereto, followed by stirring at room temperature for 5 minutes. After the reaction mixture was filtered to remove any insoluble matter and the filtrate was poured into a saturated aqueous solution of sodium chloride, the product was extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous magnesium sulfate. After the solvent was distilled off, the resulting crude product was purified by TLC (using a 10:1 mixture of chloroform and methanol as the developing solvent) to obtain 52 mg of 4′-amino-2′-cyanobiphenyl-4-yl sulfamate.

Provenance & Evidence