HCID 23508381, compound → HCID 23508486, compound

Participants

Reaction Steps

The procedure of Preparation Example 9 was repeated, except that 222 mg of 4-[N-(4-benzyloxybenzyl)-N-(3-pyridyl)amino]benzonitrile was used in place of 4-[N-(4-benzyloxybenzyl)-N-methylsulfonylamino]-phenyl methanesulfonate, and 3 ml of ethyl acetate was used in place of dioxane. The resulting mixture was stirred for 3 days under an atmospheric pressure of hydrogen. The reaction mixture was filtered to remove any insoluble matter, and the solvent was distilled off from the filtrate. The resulting crude product was purified by TLC (using a 1:1 mixture of ethyl acetate and hexane as the developing solvent) to obtain 95 mg of 4-[N-(4-hydroxybenzyl)-N-(3-pyridyl)amino]benzonitrile.

Provenance & Evidence