HCID 23508460, compound → HCID 23508548, compound

Participants

Reaction Steps

The procedure of Preparation Example 2 was repeated, except that 1.465 g of methyl 4-[(1Z)-2-cyano-2-(4-methoxyphenyl)vinyl]phenyl-carboxylate was used in place of 4′-methoxy-2-biphenylacetonitrile, and 1,2-dichloroethane was used in place of methylene chloride. The resulting crude product was purified by TLC (using a 10:1 mixture of chloroform and tetrahydrofuran as the developing solvent) to obtain 524 mg of methyl 4-[(1Z)-2-cyano-2-(4-hydroxyphenyl)vinyl]phenylcarboxylate.

Provenance & Evidence