HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Nitrobenzyl)piperidine → 4-(Piperidin-1-ylmethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Nitrobenzyl)piperidine | HCID 783541 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(Piperidin-1-ylmethyl)aniline | HCID 846150 | — |
Reaction Steps
37.0 g of 4-(piperidin-1-yl-methyl)-nitrobenzene are dissolved in 300 ml of methanol, 8.0 g of Raney nickel are added and the mixture is hydrogenated for 85 minutes with 3 bars of hydrogen at room temperature. The catalyst is filtered off and the filtrate is evaporated down.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06762180B1 |
| Source dataset | uspto-grants-2004_07 |
| ORD ID | ord-514986490c794ce8973938651f5ebda3 |
| Source note | uspto-grants-2004_07 |