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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1883797Generated: October 27, 2026

Benzenemethanamine, 4-amino-N,N-dimethyl- → methyl (3Z)-3-[[4-[(dimethylamino)methyl]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate

https://huagongshe.com/reaction/1883797

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzenemethanamine, 4-amino-N,N-dimethyl-HCID 308051—
Reactant1-Acetyl-3-(1-ethoxy-1-phenylmethylene)-6-methoxycarbonyl-2-indolinoneHCID 66685972—
Productmethyl (3Z)-3-[[4-[(dimethylamino)methyl]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylateHCID 178497160—

Reaction Steps

Prepared from 1-acetyl-3-(1-ethoxy-1-phenylmethylene)-6-methoxycarbonyl-2-indolinone and 4-(dimethylaminomethyl)-aniline Rf value: 0.6 (silica gel, methylene chloride/methanol=5:1) C26H25N3O3

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06762180B1
Source datasetuspto-grants-2004_07
ORD IDord-89dd1c1b9942489bb9982afaa3de7bf6
Source noteuspto-grants-2004_07