1-(4-AMINO-BENZYL)-PYRROLIDIN-2-ONE → HCID 178497138, compound

HRID 1883806Notes

Reaction equation

HRID 1883806 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]([O:15][CH3:16])=[O:14])[CH:11]=2)[C:6](=[C:17](OCC)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:5]1=[O:27])(=O)C.[O:28]=[C:29]1[CH2:33][CH2:32][CH2:31][N:30]1[CH2:34][C:35]1[CH:41]=[CH:40][C:38]([NH2:39])=[CH:37][CH:36]=1>>[O:28]=[C:29]1[CH2:33][CH2:32][CH2:31][N:30]1[CH2:34][C:35]1[CH:41]=[CH:40][C:38]([NH:39]/[C:17](=[C:6]2\[C:5](=[O:27])[NH:4][C:12]3[C:7]\2=[CH:8][CH:9]=[C:10]([C:13]([O:15][CH3:16])=[O:14])[CH:11]=3)/[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:37][CH:36]=1

Participants

3

Reactant 2

HCID 71485751-(4-AMINO-BENZYL)-PYRROLIDIN-2-ONEHCID 666859721-Acetyl-3-(1-ethoxy-1-phenylmethylene)-6-methoxycarbonyl-2-indolinone

Product 1

HCID 178497138HCID 178497138, compound

Procedure

Prepared from 1-acetyl-3-(1-ethoxy-1-phenylmethylene)-6-methoxycarbonyl-2-indolinone and 4-(2-oxo-pyrrolidin-1-yl-methyl)-aniline Rf value: 0.3 (silica gel, methylene chloride/methanol=20:1) C28H25N3O4

Sources & evidence

ORD record
ord-8eb63e9dff63424e8c8463ce2abbff4a
Source dataset
uspto-grants-2004_07
Patent number
US06762180B1

Reaction notes

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