tert-Butyl 4-((4-aminophenyl)methyl)piperazine-1-carboxylate → HCID 178497149, compound

HRID 1883826Notes

Reaction equation

HRID 1883826 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]([O:15][CH3:16])=[O:14])[CH:11]=2)[C:6](=[C:17](OCC)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:5]1=[O:27])(=O)C.[C:28]([O:32][C:33]([N:35]1[CH2:40][CH2:39][N:38]([CH2:41][C:42]2[CH:48]=[CH:47][C:45]([NH2:46])=[CH:44][CH:43]=2)[CH2:37][CH2:36]1)=[O:34])([CH3:31])([CH3:30])[CH3:29]>>[C:28]([O:32][C:33]([N:35]1[CH2:36][CH2:37][N:38]([CH2:41][C:42]2[CH:48]=[CH:47][C:45]([NH:46]/[C:17](=[C:6]3\[C:5](=[O:27])[NH:4][C:12]4[C:7]\3=[CH:8][CH:9]=[C:10]([C:13]([O:15][CH3:16])=[O:14])[CH:11]=4)/[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:44][CH:43]=2)[CH2:39][CH2:40]1)=[O:34])([CH3:31])([CH3:29])[CH3:30]

Participants

3

Reactant 2

HCID 12045001tert-Butyl 4-((4-aminophenyl)methyl)piperazine-1-carboxylateHCID 666859721-Acetyl-3-(1-ethoxy-1-phenylmethylene)-6-methoxycarbonyl-2-indolinone

Product 1

HCID 178497149HCID 178497149, compound

Procedure

Prepared from 1-acetyl-3-(1-ethoxy-1-phenylmethylene)-6-methoxycarbonyl-2-indolinone and 4-(4-tert.butoxycarbonyl-piperazin-1-yl-methyl)-aniline Rf value: 0.5 (silica gel, methylene chloride/methanol=10:1) C33H36N4O5

Sources & evidence

ORD record
ord-a0e2499a0b0d48a8a9c91170e776f618
Source dataset
uspto-grants-2004_07
Patent number
US06762180B1

Reaction notes

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