HCID 23507560, compound → methyl (3Z)-3-[[4-[2-(dimethylamino)ethyl-(2-methylpropanoyl)amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate

HRID 1883832Notes

Reaction equation

HRID 1883832 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]([O:15][CH3:16])=[O:14])[CH:11]=2)[C:6](=[C:17](OCC)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:5]1=[O:27])(=O)C.[CH3:28][N:29]([CH3:45])[CH2:30][CH2:31][N:32]([C:38]1[CH:44]=[CH:43][C:41]([NH2:42])=[CH:40][CH:39]=1)[C:33](=[O:37])[CH:34]([CH3:36])[CH3:35]>>[CH3:45][N:29]([CH3:28])[CH2:30][CH2:31][N:32]([C:38]1[CH:44]=[CH:43][C:41]([NH:42]/[C:17](=[C:6]2\[C:5](=[O:27])[NH:4][C:12]3[C:7]\2=[CH:8][CH:9]=[C:10]([C:13]([O:15][CH3:16])=[O:14])[CH:11]=3)/[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:40][CH:39]=1)[C:33](=[O:37])[CH:34]([CH3:36])[CH3:35]

Participants

3

Reactant 2

HCID 23507560HCID 23507560, compoundHCID 666859721-Acetyl-3-(1-ethoxy-1-phenylmethylene)-6-methoxycarbonyl-2-indolinone

Product 1

HCID 178497186methyl (3Z)-3-[[4-[2-(dimethylamino)ethyl-(2-methylpropanoyl)amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate

Procedure

Prepared from 1-acetyl-3-(1-ethoxy-1-phenylmethylene)-6-methoxycarbonyl-2-indolinone and 4-(N-(2-dimethylamino-ethyl)-N-isobutyryl-amino)-aniline Rf value: 0.5 (silica gel, methylene chloride/methanol=9:1) C31H34N4O4

Sources & evidence

ORD record
ord-157dd62b52ca448bb9275645c5a459de
Source dataset
uspto-grants-2004_07
Patent number
US06762180B1

Reaction notes

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