1-Acetyl-3-(1-ethoxy-1-phenylmethylene)-6-methoxycarbonyl-2-indolinone → HCID 178497147, compound

HRID 1883887Notes

Reaction equation

HRID 1883887 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]([O:15][CH3:16])=[O:14])[CH:11]=2)[C:6](=[C:17](OCC)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:5]1=[O:27])(=O)C.NC1C=CC=CC=1.[O:35]=[C:36]1[NH:41][CH2:40][CH2:39][N:38]([CH2:42][C:43]2[CH:49]=[CH:48][C:46]([NH2:47])=[CH:45][CH:44]=2)[CH2:37]1>>[O:35]=[C:36]1[NH:41][CH2:40][CH2:39][N:38]([CH2:42][C:43]2[CH:44]=[CH:45][C:46]([NH:47]/[C:17](=[C:6]3\[C:5](=[O:27])[NH:4][C:12]4[C:7]\3=[CH:8][CH:9]=[C:10]([C:13]([O:15][CH3:16])=[O:14])[CH:11]=4)/[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:48][CH:49]=2)[CH2:37]1

Participants

3

Reactant 2

HCID 666859721-Acetyl-3-(1-ethoxy-1-phenylmethylene)-6-methoxycarbonyl-2-indolinoneHCID 131724502HCID 131724502, compound

Product 1

HCID 178497147HCID 178497147, compound

Procedure

Prepared from 1-acetyl-3-(1-ethoxy-1-phenylmethylene)-6-methoxycarbonyl-2-indolinone and 4-(3-oxo-piperazin-1-yl-methyl)-aniline aniline Rf value: 0.46 (silica gel, methylene chloride/methanol=9:1) C28H26N4O4

Sources & evidence

ORD record
ord-0a00978d26a84067803a5fb38a583314
Source dataset
uspto-grants-2004_07
Patent number
US06762180B1

Reaction notes

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