Benzoyl chloride → HCID 178497148, compound

HRID 1883891Notes

Reaction equation

[N:1]1([CH2:7][C:8]2[CH:35]=[CH:34][C:11]([NH:12]/[C:13](=[C:20]3\[C:21](=[O:33])[NH:22][C:23]4[C:28]\3=[CH:27][CH:26]=[C:25]([C:29]([O:31][CH3:32])=[O:30])[CH:24]=4)/[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:10][CH:9]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:36](Cl)(=[O:43])[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1>>[C:36]([N:4]1[CH2:5][CH2:6][N:1]([CH2:7][C:8]2[CH:35]=[CH:34][C:11]([NH:12]/[C:13](=[C:20]3\[C:21](=[O:33])[NH:22][C:23]4[C:28]\3=[CH:27][CH:26]=[C:25]([C:29]([O:31][CH3:32])=[O:30])[CH:24]=4)/[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[CH:10][CH:9]=2)[CH2:2][CH2:3]1)(=[O:43])[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1

Participants

Reactant 2

HCID 7412Benzoyl chloride

HCID 178497143HCID 178497143, compound

Product 1

HCID 178497148HCID 178497148, compound

Procedure

Prepared from 3-Z-[1-(4-(piperazin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone and benzoyl chloride Rf value: 0.7 (silica gel, methylene chloride/methanol=10:1) C35H32N4O4

Sources & evidence

ORD record: ord-ac82bb7911074cb5add0c22578a83529
Source dataset: uspto-grants-2004_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06762180B1

Reaction notes

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