1-Benzyl-3-(trifluoroacetamido)pyrrolidine → 1-(Phenylmethyl)-N-(2,2,2-trifluoroethyl)-3-pyrrolidinamine

Participants

Reaction Conditions

Reaction Steps

A 2.64 g sample of the compound from step 447a was added dropwise to a suspension of 1.11 g of LAH in ether stirred under N2 at 0° C. After one hour, the reaction was stirred at room temperature for 6 hours. The reaction was quenched by sequential addition of 1.2 mL of water, 1.2 mL of 15% NaOH and 2.4 mL of water. The mixture was filtered, and the filtrate was concentrated to give 2.39 of the title compound.

Provenance & Evidence