Guanidine → 5,6-dihydro-3-(methylamino)benzo[f]quinazolin-1(2H)-one

Participants

Reaction Steps

Methyl 3,4-dihydro-2-hydroxy-1-naphthoate was reacted with methylguanidine in the same manner as for the analogous reaction using guanidine (example 1) to obtain 5,6-dihydro-3-(methylamino)benzo[f]quinazolin-1(2H)-one. 1H NMR (DMSO-d6, 200 MHz) δ: 2.52-2.64 (m, 2H, CH2), 2.68-2.82 (m, 2H, CH2), 2.81 (d, J=5 Hz, 3H, NCH3), 6.54 (br s, 1H, C3NH), 7.02 (ddd, J=8, 8, 2 Hz, 1H, Ar), 7.07-7.18 (m, 2H, Ar), 8.42 (dd, J=8, 2 Hz, 1H, Ar), 10.98 (br s, 1H, N2H).

Provenance & Evidence