Chlorosulfonic acid → HCID 135838097, compound

HRID 1884008Notes

Reaction equation

HRID 1884008 reaction equation
[Cl:1][S:2]([OH:5])(=O)=[O:3].[NH2:6][C:7]1[NH:16][C:15](=[O:17])[C:14]2[C:13]3[CH:18]=[CH:19][CH:20]=[CH:21][C:12]=3[CH2:11][CH2:10][C:9]=2[N:8]=1>>[NH2:6][C:7]1[NH:16][C:15](=[O:17])[C:14]2[C:13]3[CH:18]=[CH:19][C:20]([S:2]([Cl:1])(=[O:5])=[O:3])=[CH:21][C:12]=3[CH2:11][CH2:10][C:9]=2[N:8]=1

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 1358382213-Amino-5,6-dihydrobenzo[f]quinazolin-1(2H)-one

Product 1

HCID 135838097HCID 135838097, compound

Procedure

Chlorosulfonic acid (25 ml, Aldrich), cooled to 5° C. in ice, was stirred during its addition to 3-amino-1,2,5,6-tetrahydro-1-oxo-benzo[f]quinazoline (5 g, 0.025 mole) contained in a beaker immersed in an ice bath. The solution was removed from the ice bath, stirred for a further 20 min, then poured onto ice (1000 g). The solid product was removed by filtration, washed with water, and dried under high vacuum at room temperature. The sulfonyl chloride was used without further purification.

Workup

  1. customimmersed in an ice bath
  2. customThe solution was removed from the ice bath
  3. additionpoured onto ice (1000 g)
  4. customThe solid product was removed by filtration
  5. washwashed with water
  6. customdried under high vacuum at room temperature
  7. customThe sulfonyl chloride was used without further purification

Sources & evidence

ORD record
ord-2245fa28b3224562a7bd705e9195c4f5
Source dataset
uspto-grants-2004_07
Patent number
US06762188B1

Reaction notes

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