HCID 23507821, compound → HCID 23507801, compound

Participants

Reaction Steps

A solution of dodecyl 4-(4-nitrophenyl)-4-oxobutyrate (0.42 g, 1.1 mmol), in ethyl acetate (50 ml) and 10% palladium on carbon (0.10 g) were shaken under hydrogen (30-40 psi) for 10 minutes. The mixture was filtered and the filtrate concentrated in vacuo to give dodecyl 4-(4-aminophenyl)-4-oxobutyrate (0.38 g) as a white solid. 1H NMR (DMSO-d6, 300 MHz) δ: 0.86 (t, J=6.5 Hz, 3H, esterCH3), 1.10-1.37 (m, 18H, esterCH2's), 1.47-1.60 (m, 2H, esterCH), 2.57 (t, J=6.5 Hz, 2H, CH2), 3.10 (t, J=6.5 Hz, 2H, CH2), 3.98 (t, J=6.5 Hz, 2H, esterCH2), 6.04 (br s, 2H, NH2), 6.56 (d, J=8.5 Hz, 2H, Ar), 7.68 (d, J=8.5 Hz, 2H, Ar). Anal. Calculated for C22H35NO3.1/20H2O: C, 72.91; H, 9.76; N, 3.86. Found: C, 72.86; H, 9.83; N, 3.82.

Provenance & Evidence