Methyl malonyl chloride → HCID 9974187, compound

HRID 1884097Notes

Reaction equation

HRID 1884097 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH2:17])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=1.[CH3:18][O:19][C:20](=[O:25])[CH2:21][C:22](Cl)=[O:23]>>[CH3:18][O:19][C:20](=[O:25])[CH2:21][C:22]([NH:17][C:4]1[CH:5]=[CH:6][C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=2)=[C:2]([F:1])[CH:3]=1)=[O:23]

Participants

3

Reactant 2

HCID 123460Methyl malonyl chlorideHCID 219200533-Fluoro-4-[(3-fluorophenyl)methoxy]benzenamine

Product 1

HCID 9974187HCID 9974187, compoundYield 65%

Procedure

The title compound is prepared in analogy to example 1 from 3-fluoro-4-(3-fluoro-benzyloxy)-phenylamine and chlorocarbonyl-acetic acid methyl ester. Yield: 65%. Light yellow solid. MS: m/e=336.2 (M++H).

Sources & evidence

ORD record
ord-735e54990d564ad29251ddc8d8400497
Source dataset
uspto-grants-2004_07
Patent number
US06762320B2

Reaction notes

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