Methyl malonyl chloride → N-[4-(4-Fluoro-benzyloxy)-phenyl]-malonamic Acid Methyl Ester

HRID 1884101Notes

Reaction equation

HRID 1884101 reaction equation
[F:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][O:7][C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH3:17][O:18][C:19](=[O:24])[CH2:20][C:21](Cl)=[O:22]>>[CH3:17][O:18][C:19](=[O:24])[CH2:20][C:21]([NH:14][C:11]1[CH:12]=[CH:13][C:8]([O:7][CH2:6][C:5]2[CH:15]=[CH:16][C:2]([F:1])=[CH:3][CH:4]=2)=[CH:9][CH:10]=1)=[O:22]

Participants

3

Reactant 2

HCID 123460Methyl malonyl chlorideHCID 64860214-(4-Fluoro-benzyloxy)-phenylamine

Product 1

HCID 10335957N-[4-(4-Fluoro-benzyloxy)-phenyl]-malonamic Acid Methyl EsterYield 75%

Procedure

The title compound is prepared in analogy to example 1 from 4-(4-fluoro-benzyloxy)-phenylamine and chlorocarbonyl-acetic acid methyl ester. Yield: 75%. Colorless solid. MS: m/e=318.2 (M++H).

Sources & evidence

ORD record
ord-95e67ae2af074c7d847a8ff906d70895
Source dataset
uspto-grants-2004_07
Patent number
US06762320B2

Reaction notes

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