Isopropanol → HCID 9927687, compound

Participants

Reaction Steps

A solution of the 1-[2-fluoro-4-(4-fluoro-benzyloxy)-phenyl]-2,5-dimethyl-1H-pyrrole (23.7 g, 76 mmol), potassium hydroxide (8.5 g, 151 mmol), hydroxylamine HCl (62.5 g, 899 mmol) in water (125 mL) and propan-2-ol (250 mL) was heated at 100° C. for 36 h. After cooling to room temperature, the mixture was poured into water, and extracted with diethylether. The combined organic layers were then washed with brine, dried and the resulting solution was diluted with HCl in diethylether. The resulting precipitate was then filtered off to afford the title compound (15.2 g, 74%) as a light brown solid. MS: m/e=236.0 (M+−Cl).

Provenance & Evidence