Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Tin atom | HCID 5352426 | — |
| Reactant | 1-Fluoro-4-[2-(4-nitrophenyl)ethenyl]benzene | HCID 54445635 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 202244 | HCID 202244 | 85.3% |
Reaction Steps
A solution of 7.3 g (30 mmol) of 4-[2-(4-fluoro-phenyl)-vinyl]-1-nitro-benzene in 250 ml of ethanol is treated with 80 ml of aqueous 25% hydrochloric acid. The mixture is heated at 110° C. and 5 g (42 mmol) of tin is added portionwise. After stirring for 3 h at 110° C. the suspension is cooled to room temperature, neutralised by additon of aqueous sodium hydroxide and extracted 3 times with dichloromethane. Drying over magnesium sulfate and evaporations yields 5.46 g (85%) of a colorless solid. MS: m/e=214.2 (M++H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06762320B2 |
|---|
| Source dataset | uspto-grants-2004_07 |
|---|
| ORD ID | ord-a69baf5707a34591870d68d5b845b3de |
|---|
| Source note | uspto-grants-2004_07 |
|---|
