反应详情

温度

80 °C

3-[(4′-Methoxy[1,1′-biphenyl]-4-yl)sulfonyl]amino-2-oxo-5-[(phenylamino)methyl]-tetrahydrofuran: To a solution of methyl 2-[(4′-methoxy[1,1′-biphenyl]-4-yl)sulfonyl]amino-4,5-epoxypentanoate 1d (0.5 g, 1.28 mmol) in aniline (0.17 mL, 1.92 mmol) is added magnesium perchlorate (2 mg, 0.009 mmol) and the resulting mixture is heated for 4 h at 80° C. The resulting mixture is cooled to room temperature, and then the mixture is diluted with water, and extracted three times with EtOAc. The combined EtOAc layer is washed with water, brine, dried over MgSO4 and concentrated to an oil which is purified by column chromatography eluting with hexane/EtOAc (7:3) to give the desired product.

1. temperatureThe resulting mixture is cooled to room temperature
2. extractionextracted three times with EtOAc
3. washThe combined EtOAc layer is washed with water, brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated to an oil which
6. customis purified by column chromatography
7. washeluting with hexane/EtOAc (7:3)