Methyl 2-[(4'-methoxy[1,1'-biphenyl]-4-yl)sulfonyl]amino-4,5-epoxypentanoate → 2-[(4'-Methoxy[1,1'-biphenyl]-4-yl)sulfonyl]amino-4-hydroxy-5-[(6-ethoxy-2-benzothiazolyl)thio]-pentanoic Acid

HRID 1884287Notes

Reaction equation

HRID 1884287 reaction equation
[CH2:1]([O:3][C:4]1[CH:13]=[CH:12][C:7]2[N:8]=[C:9]([SH:11])[S:10][C:6]=2[CH:5]=1)[CH3:2].[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][C:25]([S:28]([NH:31][CH:32]([CH2:37][CH:38]3[O:40][CH2:39]3)[C:33]([O:35]C)=[O:34])(=[O:30])=[O:29])=[CH:24][CH:23]=2)=[CH:18][CH:17]=1>>[CH3:14][O:15][C:16]1[CH:17]=[CH:18][C:19]([C:22]2[CH:23]=[CH:24][C:25]([S:28]([NH:31][CH:32]([CH2:37][CH:38]([OH:40])[CH2:39][S:11][C:9]3[S:10][C:6]4[CH:5]=[C:4]([O:3][CH2:1][CH3:2])[CH:13]=[CH:12][C:7]=4[N:8]=3)[C:33]([OH:35])=[O:34])(=[O:29])=[O:30])=[CH:26][CH:27]=2)=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 12073922Methyl 2-[(4'-methoxy[1,1'-biphenyl]-4-yl)sulfonyl]amino-4,5-epoxypentanoateHCID 178466040HCID 178466040, compound

Product 1

HCID 235082392-[(4'-Methoxy[1,1'-biphenyl]-4-yl)sulfonyl]amino-4-hydroxy-5-[(6-ethoxy-2-benzothiazolyl)thio]-pentanoic Acid

Procedure

Example 25 is prepared from 6-ethoxy-2-mercaptobenzothiazole and 1d using the procedure described for compound 20.

Sources & evidence

ORD record
ord-b34de555bab2487d99828e5aa1286bf6
Source dataset
uspto-grants-2004_07
Patent number
US06762198B2

Reaction notes

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