Piperidine → HCID 69928964, compound

Participants

Reaction Steps

To a solution of the compound J (250 mg, 0.38 mmol) dissolved in 10 mL of DMF was added piperidine (0.5 mL). The solution was stirred 10 min at room temperature. The solvent was evaporated and the residue was purified by flash chromatography using a gradient solvent system 10% MeOH/CH2Cl2 to 100% MeOH. After evaporation of the solvent 53 mg (33%) of the compound K was isolated as a yellow oil. 1H NMR 500 MHz (CD3OD) δ5.87 (m, 1H), 5.22 (m, 2H), 4.54 (dt, J=5.6 Hz, 1.2 Hz, 2H), 3.93 (t, J=7 Hz, 2H), 2.92 (s, 2H), 2.72 (t, J=8 Hz, 2H), 2.68 (t, J=7.5 Hz, 2H), 2.45 (t, J=8 Hz, 2H), 210 (s, 3H), 1.96 (s, 3H), 1.58-1.42 (br, 4H), 1.38 (s, 6H), 1.30 (m, 2H).

Provenance & Evidence