Morpholine → HCID 86585721, compound

Participants

Reaction Steps

To a solution of the compound L (34 mg, 53 μmol) in 4 mL of THF was added tetrakis(triphenylphosphine)palladium(0) (6 mg, 5.3 μmol) followed by morpholine (46 μL, 0.53 mmol). After evaporation of the solvent, the residue was purified by flash chromatography using a gradient solvent system 10% MeOH/CH2Cl2 to 100% MeOH to give 12 mg (40%) of the compound M as a yellow solid. 1H NMR 400 MHz (CDCl3) δ7.05 (s, 1H), 6.10 (s, 1H), 5.16 (s, 1H), 4.51 (dd, J=8 Hz, 4.5 Hz, 1H), 4.35 (dd, J=8 Hz, 4.5 Hz, 1H), 3.93 (t, J=7 Hz, 2H), 3.72 (t, J=5.4 Hz, 1H), 3.17 (m, 2H), 2.93 (s, 2H), 2.90 (m, 1H), 2.72 (m, 2H), 2.40 (t, J=8 Hz, 2H), 2.19 (t, J=7.5 Hz, 2H), 2.12 (s, 3H), 1.98 (s, 3H), 1.78-1.52 (br, 6H), 1.52-1.38 (br, 4H), 1.42 (s, 6H), 1.30 (m, 2H).

Provenance & Evidence