HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(1,3-Benzodioxol-5-yl)-1-isopropylurea → 1-Isopropyl-6,7-methylenedioxy-4-(2-chloro-4,5-methylenedioxyphenyl)-3,4-dihydro-quinazolin-2(1h)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(1,3-Benzodioxol-5-yl)-1-isopropylurea | HCID 100555 | — |
| Reactant | 6-Chloropiperonal | HCID 140014 | — |
| Product | 1-Isopropyl-6,7-methylenedioxy-4-(2-chloro-4,5-methylenedioxyphenyl)-3,4-dihydro-quinazolin-2(1h)-one | HCID 12150180 | 65% |
Reaction Steps
This compound was synthesized from N-isopropyl-N-[3.4-(methylenedioxy)-phenyl]urea (410 mg) and 6-chloropiperonal (350 mg) by the procedure described in example 10 in 65% yield. 1H NMR (CDCl3): 6.86 (s, 1H), 6.77 (s, 1H), 6.48 (s, 1H), 6.40 (s, 1H), 5.95 (s, 4H), 5.66 (d, J=2.5, 1H), 5.21 (s, 1H), 4.48 (m, 1H), 1.53 (d, J=6.5, 6H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06765006B2 |
| Source dataset | uspto-grants-2004_07 |
| ORD ID | ord-0195ba5497f04fe6abe4c16bc9422980 |
| Source note | uspto-grants-2004_07 |