Water → HCID 9956750, compound

Participants

Reaction Steps

A solution of 3-[(4′-chloro[1,1′-biphenyl]-4-yl)sulfanyl]-2-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]propanoic acid (4.6 g) in 30 ml of DMF was added dropwise to a stirred solution of Oxone® (13.5 g) in 75 mL of DMF and 20 mL of water at 45° C. After stirring for 2 h, the solvent was removed and the residue was partitioned between ethyl acetate and brine. The residue was columned on a small pad of silica gel eluting with chloroform to furnish 3.9 g of the title compound as a white foam.

Provenance & Evidence