4-(2-Piperidin-1-yl-ethoxy)-phenylamine → HCID 178418775, compound

HRID 1884448Notes

Reaction equation

HRID 1884448 reaction equation
[N:1]1([CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][C:22](=[O:27])[C:21]2=[CH:28]O>>[Cl:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][C:22](=[O:27])[C:21]2=[CH:28][NH:16][C:13]1[CH:12]=[CH:11][C:10]([O:9][CH2:8][CH2:7][N:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 30160254-(2-Piperidin-1-yl-ethoxy)-phenylamineHCID 1784190365-chloro-3-(hydroxymethylidene)-1H-indol-2-one

Product 1

HCID 178418775HCID 178418775, compoundYield 57%

Procedure

In a manner similar to that described in Example 231, 4-(2-piperidin-1-yl-ethoxy)-phenylamine (600 mg, 1.2 equiv.) and 5-chloro-3-hydroxymethylene-1,3-dihydro-indol-2-one (444 mg, 2.27 mmol, 1 equiv.) are reacted to give the named compound as a yellow solid (513 mg, 57%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-b659b48b5b124f7ab4e7fdac7d577fff
Source dataset
uspto-grants-2004_07
Patent number
US06765012B2

Reaction notes

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