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1,2-Dimethoxyethane → 3-(3,5-Di-t-butyl-4-hydroxyphenyl)-3-methoxybenzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Bromo-2,6-di-tert-butylphenol | HCID 70829 | — |
| 反応物 | 5-Formyl-2-methoxyphenylboronic acid | HCID 2734367 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-(3,5-Di-t-butyl-4-hydroxyphenyl)-3-methoxybenzaldehyde | HCID 22268285 | 61% |
反応手順
The intermediate 3-(3,5-di-t-butyl-4-hydroxyphenyl)-3-methoxybenzaldehyde was prepared in a manner similar to the procedure described in Example 1b using 4-bromo-2,6-di-t-butylphenol (0.50 g, 1.75 mmol), 2-methoxy-5-formylphenyl boronic acid (0.315 g, 1.75 mmol), tetrakis(triphenylphosphine)palladium(0) (0.20 g, 0.175 mmol), K2CO3 (0.95 g, 7.0 mmol), dimethoxyethane (15 mL) and H2O (1 mL); 367 mg, 61% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06765013B2 |
| 出典データセット | uspto-grants-2004_07 |
| ORD ID | ord-f08814cd9f1348a49bf5d56a932e6311 |
| 出典メモ | uspto-grants-2004_07 |