HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenethylamine → HCID 23505567, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenethylamine | HCID 1001 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Tert-butyl 4-fluoro-3-methylbenzoate | HCID 11042021 | — |
| Catalyst | Benzoyl Peroxide | HCID 7187 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | HCID 23505567 | HCID 23505567 | 64.6% |
Reaction Steps
According to the procedure of Preparation 4 (b), except using tert-butyl 4-fluoro-3-methylbenzoate (6.25 g, 29.7 mmole), N-bromosuccinimide (5.75 g, 32.3 mmole), benzoyl peroxide (375 mg, 1.6 mmole), CCl4 (50 mL), and 2-phenethylamine (19 mL, 151 mmole), the title compound (6.32 g, 64%) was prepared as a yellow oil following flash chromatography on silica gel (gradient: 20-40% EtOAc/hexanes): MS (ES) m/e 330.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06765005B2 |
| Source dataset | uspto-grants-2004_07 |
| ORD ID | ord-31129b404b5e4c07a0049a6512ce89ae |
| Source note | uspto-grants-2004_07 |