HRID1884538

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)C[C@H]1Nc2ccc(C(=O)O)cc2CN(C)C1=O

HCID11220043

未命名化合物

HCID11401058

N-METHYL-1-(1-METHYL-1H-INDOL-2-YL)-METHANAMINE

C11H14N2

HCID14905981

未命名化合物

HCID53726847

未命名化合物

PRODUCTS

生成物

结构：CN(Cc1cc2cc(OCc3ccccc3)ccc2n1C)C(=O)c1ccc2c(c1)CN(C)C(=O)[C@@H](CO)N2

HCID53680873

未命名化合物

收率 94%

PROCEDURE

实验过程

According to the procedure of Example 1 (a), except substituting 5-benzyloxy-1-methyl-2-(methylaminomethyl)indole (0.42 g, 1.50 mmole) for the 1-methyl-2-(methylaminomethyl)indole, and substituting (2R)-2-(hydroxymethyl)-4-methyl-3-oxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carboxylic acid (0.34 g, 1.37 mmole) for the (2R)-2-[(carbomethoxy)methyl]-4-methyl-3-oxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carboxylic acid, the title compound (0.66 g, 94%) was prepared as an off-white solid: MS (ES) m/e 513 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-53d6fcc446b743c9b840d87fc80d8b50
来源数据集: uspto-grants-2004_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06765005B2
来源说明: uspto-grants-2004_07

反应 SMILES

[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH3:18])[C:13]([CH2:19][NH:20][CH3:21])=[CH:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CN1C2C(=CC=CC=2)C=C1CNC.[OH:35][CH2:36][C@@H:37]1[C:43](=[O:44])[N:42]([CH3:45])[CH2:41][C:40]2[CH:46]=[C:47]([C:50](O)=[O:51])[CH:48]=[CH:49][C:39]=2[NH:38]1.C(C[C@@H]1C(=O)N(C)CC2C=C(C(O)=O)C=CC=2N1)(OC)=O>>[CH3:21][N:20]([CH2:19][C:13]1[N:14]([CH3:18])[C:15]2[C:11]([CH:12]=1)=[CH:10][C:9]([O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[CH:17][CH:16]=2)[C:50]([C:47]1[CH:48]=[CH:49][C:39]2[NH:38][C@H:37]([CH2:36][OH:35])[C:43](=[O:44])[N:42]([CH3:45])[CH2:41][C:40]=2[CH:46]=1)=[O:51]