Dicyclohexylcarbodiimide → HCID 23506182, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1,3-dimethylbarbituric acid (2.5 g, 16.01 mmol), 9-fluorenylcarboxylic acid (5.05 g, 24.01 mmol), 4-dimethylaminopyridine (0.98 g, 8.00 mmol) in dry CH2Cl2 (15 ml) was cooled to 0° C. and 1,3-dicyclohexylcarbodiimide (3.30 g, 16.01 mmol) added. The reaction mixture was stirred at room temperature overnight and filtered. The solid was washed with CH2Cl2 (50 ml) and the combined solution was washed with 2 N HCl solution (5 ml). The organic phase was dried over MgSO4 and evaporated. The residue was crystallised from recrystallised from MeOH giving 5-(9-fluorenyl-carbonyl)-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione 5 (2.85 g, 69%).

Provenance & Evidence