HCID 10219854, compound → Gabapentin

Participants

Reaction Steps

A solution of 2.01 g (0.01 mol) of 1-(nitromethyl)-cyclohexyl-acetic acid in 50 ml of methanol is hydrogenated in the presence of 0.2 g of palladium oil activated carbon at atmospheric pressure. The catalyst is filtered off and the filtrate is concentrated to 10 ml. 20 ml of tetrahydrofuran is added to the residue and the precipitated crystals were filtered off and dried to yield 1.3 g (80%) of the title compound. Mp: 164-169° C.

Provenance & Evidence