関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Indole | HCID 798 | — |
| 反応物 | 1-Benzylpiperidin-3-one hydrochloride hydrate | HCID 2760896 | — |
| 反応物 | KOH isopropanol | HCID 23443544 | — |
| 生成物 | 3-(1-benzyl-1,2,5,6-tetrahydropyridine-3-yl)-1H-indole | HCID 15813849 | — |
反応手順
A mixture of indole (29, 17 mmol) and 1-benzyl-piperidin-3-one hydrochloride hydrate (7.7 g, 34 mmol) and 2N KOH/isopropanol is heated at 80° C. for 14 hours, cooled to room temperature, poured over ice/water and extracted with ethyl acetate. The extracts are combined, washed with water, dried over Na2SO4 and concentrated in vacuo to afford the title product, identified by HPLC and mass spectral analyses.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06767912B2 |
|---|
| 出典データセット | uspto-grants-2004_07 |
|---|
| ORD ID | ord-e2f38010b453419d818fe02f353976e3 |
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| 出典メモ | uspto-grants-2004_07 |
|---|
