Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Nitrogen mustard hydrochloride | HCID 5935 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,4-Dihydroxy-9H-thioxanthen-9-one | HCID 23504944 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 10067305 | HCID 10067305 | — |
Reaction Steps
A solution of 0.5 g of 1,4-dihydroxythioxanthone in 20 ml of dimethylformamide is stirred for 0.5 h at room temperature with 6 g of potassium carbonate under anhydrous conditions. Mechlorethamine hydrochloride (0.4 g) is then added and the heterogeneous mixture was stirred for 12 h at 50° C. Water is added and the mixture extracted with ethyl acetate. The ethyl acetate solution is washed with water, dried with sodium sulfate, passed through a plug of alumina and concentrated under vacuum to produce 0.4 g (55%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06767919B2 |
|---|
| Source dataset | uspto-grants-2004_07 |
|---|
| ORD ID | ord-44a09621dacc41b8b577e344a03877b2 |
|---|
| Source note | uspto-grants-2004_07 |
|---|
