Isopropanol → HCID 178497917, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2,6-dichloropurine (17 g, 90 mmol) in 300 ml of 1-pentanol are added 37.8 g (250 mmol) of methyl-3-aminobenzoate and stirred for 8 hours at 75° C. After cooling to RT, 200 ml of isopropanol is added and the mixture is stirred for 1 h. After filtration, the precipitate is taken up into MeOH/H2O and treated with NaHCO3 to pH >8. After filtration, the product ist washed with H2O and MeOH and dried to obtain 25.4 g (93% yield) of 3-(2-chloro-9H-purin-6-yl-amino)-benzoic acid methyl ester, Rf=0.5; (CH2Cl2/MeOH (9/1)); m.p. 242° C.; ESI-MS: 304 (M+H)+.

Provenance & Evidence