4-Phenylbutyric Acid → N-(4phenylbutanoyl)-L-alanine iso-butyl ester

HRID 1884934Notes

Reaction equation

HRID 1884934 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][C:10]([OH:12])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH2:14]([O:18][C:19](=[O:23])[C@H:20]([CH3:22])[NH2:21])[CH:15]([CH3:17])[CH3:16]>>[CH2:14]([O:18][C:19](=[O:23])[C@H:20]([CH3:22])[NH:21][C:10](=[O:12])[CH2:9][CH2:8][CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH:15]([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 47754-Phenylbutyric AcidHCID 865849812-Methylpropyl (2S)-2-aminopropanoate hydrochloride

Product 1

HCID 15481769N-(4phenylbutanoyl)-L-alanine iso-butyl ester

Procedure

Following General Procedure B and using 4-phenylbutanoic acid (Aldrich) and L-alanine iso-butyl ester hydrochloride (from Example B above), the title compound was prepared as an oil. The reaction was monitored by tlc on silica get and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.

Workup

  1. customget
  2. custompurification
  3. extractionwas by extraction with Et2O

Sources & evidence

ORD record
ord-20d481dc4341411f81296c687aedac3f
Source dataset
uspto-grants-2004_07
Patent number
US06767918B2

Reaction notes

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