3,4-Dichlorophenylacetic acid → 2-[(3,4Dichlorophenyl)acetamido]butyric acid isobutyl ester

HRID 1884937Notes

Reaction equation

HRID 1884937 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[CH:6][C:7]=1[Cl:8].[NH2:13][CH:14]([CH2:22][CH3:23])[C:15]([O:17][CH2:18][CH:19]([CH3:21])[CH3:20])=[O:16]>>[CH2:18]([O:17][C:15](=[O:16])[CH:14]([NH:13][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=1)[CH2:22][CH3:23])[CH:19]([CH3:20])[CH3:21]

Participants

3

Reactant 2

HCID 798743,4-Dichlorophenylacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 543898612-[(3,4Dichlorophenyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure I above and using 3,4-dichlorophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure J above) the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Sources & evidence

ORD record
ord-afc7a8721cb741bdac96baf9b5931514
Source dataset
uspto-grants-2004_07
Patent number
US06767918B2

Reaction notes

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