2,4-Dichlorophenylacetic acid → 2-[(2,4-Dichlorophenyl)acetamido]butyric acid isobutyl ester

HRID 1884945Notes

Reaction equation

HRID 1884945 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:10]([OH:12])=O.[NH2:13][CH:14]([CH2:22][CH3:23])[C:15]([O:17][CH2:18][CH:19]([CH3:21])[CH3:20])=[O:16]>>[CH2:18]([O:17][C:15](=[O:16])[CH:14]([NH:13][C:10](=[O:12])[CH2:9][C:3]1[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=1[Cl:1])[CH2:22][CH3:23])[CH:19]([CH3:20])[CH3:21]

Participants

3

Reactant 2

HCID 882092,4-Dichlorophenylacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 541261332-[(2,4-Dichlorophenyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure I above and using 2,4-dichlorophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure J above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-bc733bb5a370415a9420b2b3db72039a
Source dataset
uspto-grants-2004_07
Patent number
US06767918B2

Reaction notes

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