Thiophene-3-methanol → HCID 53951305, compound

HRID 1884962Notes

Reaction equation

HRID 1884962 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([NH:11][C@H:12]([C:14]([OH:16])=[O:15])[CH3:13])=[O:10])[CH:5]=[CH:6][CH:7]=1.[S:17]1[CH:21]=[CH:20][C:19]([CH2:22]O)=[CH:18]1>>[S:17]1[CH:21]=[CH:20][C:19]([CH2:22][O:15][C:14](=[O:16])[C@H:12]([CH3:13])[NH:11][C:9](=[O:10])[CH2:8][C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)=[CH:18]1

Participants

3

Reactant 2

HCID 123570Thiophene-3-methanolHCID 15481783N-(3-chlorophenylacetyl)alanine

Product 1

HCID 53951305HCID 53951305, compound

Procedure

Following General Procedure C above, and using N-(3-chlorophenylacetyl alanine (from Example D above) and 3-thiophenemethanol (Aldrich) the title compound can be prepared. The reaction was monitored by tlc on silica gel and purification was by liquid chromatography using 3:7 EtOAc:hexane as the eluant.

Sources & evidence

ORD record
ord-1685fe93cc19482ea733c2d67b2d4f39
Source dataset
uspto-grants-2004_07
Patent number
US06767918B2

Reaction notes

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