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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1885011Generated: October 27, 2026

1-Ethynyl-4-fluorobenzene → Z-4-fluorostyryl 2-chlorobenzylsulfide

https://huagongshe.com/reaction/1885011

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Ethynyl-4-fluorobenzeneHCID 522627—
Reactant2-Chlorobenzyl mercaptanHCID 580759—
ReactantSodiumHCID 5360545—
ProductZ-4-fluorostyryl 2-chlorobenzylsulfideHCID 86588942—

Reaction Steps

A solution of 4-fluorophenylacetylene (0.02 mol) and 2-chlorobenzyl mercaptan (0.02 mol) and metallic sodium (0.02 g atom) was subjected to Procedure 2 to form (Z)-4-fluorostyryl 2-chlorobenzylsulfide. The title compound was obtained in 74% yield following oxidation. 1HNMR (CDC13) δ4.55 (2H, s), 6.66 (1H, d, JH,H=11.94), 7.20-7.65 (8H aromatic+1H ethylenic).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06767926B1
Source datasetuspto-grants-2004_07
ORD IDord-fa6c3a3b9c174fc3b85341b248261eec
Source noteuspto-grants-2004_07