HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 2222571, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | L-Serine, methyl ester, hydrochloride (1:1) | HCID 2723730 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 2222571 | HCID 2222571 | 98.9% |
Reaction Steps
A solution of benzoyl chloride (17 g) in ethyl acetate (40 ml) is added dropwise, with stirring, in an ice-cold mixture of L-serine methyl ester, hydrochloride (15.5 g), water (100 ml), sodium bicarbonate (21.8 g), and ethyl acetate (100 ml). After stirring for 2 hours, the organic phase is separated, dried over sodium sulfate, and evaporated to give crystalline N-benzoyl-L-serine methyl ester (22.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06768008B2 |
| Source dataset | uspto-grants-2004_07 |
| ORD ID | ord-818d356141974c7183d94f1ab5f290d7 |
| Source note | uspto-grants-2004_07 |