Hydrochloric Acid → HCID 54320299, compound

Participants

Reaction Steps

Then, 10.1 g of LiAlH4 was added to 217 ml of dry ether, and under stirring, a solution of the above 4-propoxyvaleric acid in 44 ml of ether was added dropwise at below 10° C. in 3.5 hours. After the addition, the mixture was raised in temperature to 20°-25° C., stirred for 3 hours and then leftstanding for 12 hours. An aqueous 5%-hydrochloric acid solution was added to acidify the mixture (pH 1), which was then subjected to extraction with ether. The ether layer was washed successively with 5%-NaOH aqueous solution and saturated saline water, followed by drying with anhydrous magnesium sulfate, distilling-off of ether and vacuum distillation to obtain 26 g of (R)-4-propoxypentanol as a fraction at 109°-117° C./35 mmHg.

Provenance & Evidence