Sodium Iodide → HCID 67901183, compound

Participants

Reaction Steps

To an ice cooled solution of sodium iodide (900 mg, 6 mmol) in acetone was added a solution of diphenylmethyl 7-t-butoxycarbonylamino-3-[(Z)-3-chloro-1-propen-1-yl]-3-cephem-4-carboxylate (VIa) (1.08 g, 2 mmol) in acetone (2.5 ml). The mixture was stirred while being cooled in an ice bath for 3.5 hours, and was concentrated under reduced pressure. The residue was diluted with ethyl acetate and aqueous sodium thiosulfate solution. The organic layer was separated, dried over magnesium sulfate, and concentrated. 923mg of the title product was obtained as a yellow powder after crystallization from a small volume of ethanol (73% yield).

Provenance & Evidence