HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-m-cresol → HCID 11725437, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-m-cresol | HCID 17819 | — |
| Reactant | 3-Butyryl-4-chloro-8-methoxyquinoline | HCID 11777567 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 11725437 | HCID 11725437 | 34.1% |
Reaction Steps
3-Butyryl-4-chloro-8-methoxyquinoline (3.95 g, 15 mmol), 4-amino-3-methylphenol (2.46 g, 20 mmol) and 1,4-dioxan (15 ml) were warmed briefly to reflux, then the solid filtered off and washed with ethyl acetate. Conversion to free base and recrystallisation from ethanol gave 3-butyryl-4-(4-hydroxy-2-methylphenylamino)-8-methoxyquinoline (1.79 g, 34%), m.p. 252°-253°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05143920 |
| Source dataset | uspto-grants-1992_09 |
| ORD ID | ord-5e2f174422da4ec2988f1732e53a7e6c |
| Source note | uspto-grants-1992_09 |