反应详情

2-Fluoro-4-aminophenol (0.8 g, 6 mmol) and 3-butyryl-4-chloro-8-methoxyquinoline (1.5 g, 5.7 mmol) were heated together under reflux in 1,4-dioxan (50 ml) for 1 hour. The solvent was evaporated and the residue was dissolved in dichloromethane, washed with water, sodium hydrogen oarbonate solution and brine then dried and evaporated. The residue was recrystallised from methanol-water to afford 3-butyryl-4-(3-fluoro-4-hydroxyphenylamino)-8-methoxyquinoline, m.p. 266°-268°.

1. customThe solvent was evaporated
2. dissolutionthe residue was dissolved in dichloromethane
3. washwashed with water, sodium hydrogen oarbonate solution and brine
4. customthen dried
5. customevaporated
6. customThe residue was recrystallised from methanol-water