HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 3-Butyryl-4-chloro-8-fluoroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 3-butyryl-8-fluoro-4(1H)-quinolone | HCID 10331542 | — |
| Product | 3-Butyryl-4-chloro-8-fluoroquinoline | HCID 10444883 | — |
Reaction Steps
3-Butyryl-8-fluoro-4(1H)-quinolone (2.7 g, 12 mmol) and phosphoryl chloride (40 ml) were heated at reflux for 3 hours. Excess phosphoryl chloride was evaporated in vacuo. the residue poured onto ice and neutralised with aqueous ammonia. Filtration and washing with water gave 3-butyryl-4-chloro-8-fluoroquinoline ((1.75 g), m.p. 57°-60°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05143920 |
| Source dataset | uspto-grants-1992_09 |
| ORD ID | ord-0827d1bcd53440b29cbe21ef14fc5e4f |
| Source note | uspto-grants-1992_09 |