HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-m-cresol → 3-Butyryl-4-(4-hydroxy-2-methylphenylamino)-8-fluoroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-m-cresol | HCID 17819 | — |
| Reactant | 3-Butyryl-4-chloro-8-fluoroquinoline | HCID 10444883 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Butyryl-4-(4-hydroxy-2-methylphenylamino)-8-fluoroquinoline | HCID 10042756 | 50.7% |
Reaction Steps
3-butyryl-4-chloro-8-fluoroquinoline (1.75 g, 7 mmol), 4-amino-3-methylphenol (1.3 g, 10 mmol) and 1,4-dioxan (50 ml) were heated at reflux for 6.5 hours, then the solvent evaporated and the product converted to free base. Recrystallisation from methanol gave 3-butyryl-4-(4-hydroxy-2-methylphenylamino)-8-fluoroquinoline (1.2 g), m.p. 205°-207°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05143920 |
| Source dataset | uspto-grants-1992_09 |
| ORD ID | ord-77dbfa8c23374342b85308553ee35733 |
| Source note | uspto-grants-1992_09 |