Acetic Anhydride → HCID 10249934, compound

Participants

Reaction Steps

3-Butyryl-4-(4-hydroxy-2-methylphenylamino)-8-methoxyquinoline (1.75 g, 5 mmol) was dissolved in a mixture of acetic anhydride (10 ml) and pyridine (10 ml), stirred for 18 hours at room temperature, then the solvent evaporated, the product dissolved in dichloromethane and washed with aqueous sodium bicarbonate. Dryinq, evaporation, and recrystallisation from ethyl acetate/petroleum ether gave 3-butyryl-4-(4-acetoxy-2-methylphenylamino)-8-methoxyquinoline (1.55 g, 79%), m.p. 167°-169°.

Provenance & Evidence