反应详情

A solution of 3-isobutyryl-4-chloro-8-methoxyquinoline (1.32 g, 5 mmol) and 4-amino-3-methylphenol (0.62 g, 5 mmol) in dioxan (50 ml) was heated at reflux for 1 hour, then cooled and the solid filtered off. This was taken up in a hot mixture of ethanol and tributylamine, cooled, and the solid filtered off. Recrystallisation from ethanol gave 3-isobutyryl-4-(4-hydroxy-2-methylphenylamino)-8-methoxyquinoline (0.97 g, 55%), m.p. 243°-5°.

1. temperatureat reflux for 1 hour
2. temperaturecooled
3. filtrationthe solid filtered off
4. additionThis was taken up in a hot mixture of ethanol and tributylamine
5. temperaturecooled
6. filtrationthe solid filtered off
7. customRecrystallisation from ethanol