2-Pyridone → HCID 9926549, compound

Participants

Reaction Steps

A mixture of 1.4 g of 2,2-dimethyl-3-formyl-4-bromo-6-cyano-3-chromene (m.p. 124°-125°; obtainable by dropwise addition of a solution of 2,2-dimethyl-5-cyano-5-chromanone in chloroform to a mixture of equal volume parts of DMF and PBr3 in chloroform and subsequent boiling for 11 hours), 0.9 g of 1H-2-pyridone, 3 g of K2CO3 and 20 ml of DMF is stirred at 60° for 1 hour. The mixture is diluted with ethyl acetate and filtered, and customary working up of the filtrate gives 2,2-dimethyl-3-formyl-4-(1,2-dihydro-2-oxo-1-pyridyl)-6-cyano-3-chromene ("A") m.p. 190°-192° C.

Provenance & Evidence