HCID 14857301, compound → HCID 14857302, compound

HRID 1885215Notes

Reaction equation

HRID 1885215 reaction equation
[CH3:1][C:2]1([CH3:24])[C:11]([CH2:12][OH:13])=[C:10]([N:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]2=[O:20])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:21]([O-])=O)[CH:8]=2)[O:3]1>CO.[Pd]>[CH3:1][C:2]1([CH3:24])[C:11]([CH2:12][OH:13])=[C:10]([N:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]2=[O:20])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([NH2:21])[CH:8]=2)[O:3]1

Participants

4

Reactant 1

HCID 14857301HCID 14857301, compound

Product 1

HCID 14857302HCID 14857302, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 1 g of 2,2-dimethyl-3-hydroxymethyl-4-(1,2-dihydro-2-oxo-1-pyridyl)-6-nitro-3-chromene in 25 ml of methanol is hydrogenated on 0.5 g of 5% Pd-C at 20° C. and at 1 bar until hydrogenation is complete. The mixture is filtered, evaporated and 2,2-dimethyl-3-hydroxymethyl-4-(1,2-dihydro-2-oxo-1-pyridyl)-6-amino-3-chromene is obtained.

Workup

  1. filtrationThe mixture is filtered
  2. customevaporated

Sources & evidence

ORD record
ord-d1f1040a45bf4edebcbc1297bf5a76f5
Source dataset
uspto-grants-1992_09
Patent number
US05143924

Reaction notes

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